Devices, methods, and systems for variable alarm setpoints and priorities are described herein. A method can include receiving, by a computing device, process data from equipment at an industrial site over a period of time, calculating, by the computing device, a rate of change of a process variable associated with a process at the industrial site based on the process data, updating, by the computing device, the rate of change of the process variable with the calculated rate of change, storing the updated rate of change of the process variable in memory of the computing device, determining, by the computing device, an alarm priority, an unsafe level, or an alarm limit based on the updated rate of change, and transmitting the alarm priority, the unsafe level, or the alarm limit to an event and alarm system.